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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
16.67
Human Site:
S1471
Identified Species:
26.19
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1471
R
K
R
K
P
S
T
S
D
D
S
D
S
N
F
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
A1518
T
V
P
K
P
K
R
A
P
K
Q
K
K
V
V
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
A1504
T
A
P
K
P
K
R
A
P
K
Q
K
K
V
V
Dog
Lupus familis
XP_537646
1532
174610
S1472
R
K
R
K
P
S
T
S
D
D
S
D
S
N
F
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1467
R
K
R
K
P
S
S
S
D
S
S
D
S
D
F
Rat
Rattus norvegicus
P41516
1526
173202
S1467
R
K
R
M
P
S
S
S
D
S
S
D
S
E
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
E1501
G
I
S
G
S
G
P
E
S
S
P
G
W
L
K
Chicken
Gallus gallus
O42130
1553
174974
S1493
T
S
S
S
D
S
D
S
D
F
G
S
R
P
S
Frog
Xenopus laevis
NP_001082502
1579
178601
K1486
K
S
K
A
A
A
K
K
P
S
S
D
S
E
D
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
S1480
V
K
P
L
S
S
D
S
D
S
A
G
P
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
D1387
G
G
N
V
G
S
D
D
D
G
N
A
S
D
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
F1456
K
S
K
A
V
T
D
F
F
G
A
S
K
K
N
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
D1388
L
D
D
V
T
S
G
D
A
A
L
A
A
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S1405
K
K
S
S
S
V
M
S
R
L
A
D
N
K
E
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
D1369
D
S
Y
T
D
R
E
D
S
N
K
D
E
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
13.3
13.3
100
N.A.
80
73.3
N.A.
0
20
20
26.6
N.A.
20
N.A.
0
6.6
P-Site Similarity:
100
20
20
100
N.A.
93.3
80
N.A.
0
20
40
33.3
N.A.
33.3
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
14
7
7
0
14
7
7
20
14
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
7
0
14
0
27
20
47
14
0
47
0
20
20
% D
% Glu:
0
0
0
0
0
0
7
7
0
0
0
0
7
14
7
% E
% Phe:
0
0
0
0
0
0
0
7
7
7
0
0
0
0
27
% F
% Gly:
14
7
0
7
7
7
7
0
0
14
7
14
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
20
40
14
34
0
14
7
7
0
14
7
14
20
14
7
% K
% Leu:
7
0
0
7
0
0
0
0
0
7
7
0
0
7
7
% L
% Met:
0
0
0
7
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
7
7
0
7
14
7
% N
% Pro:
0
0
20
0
40
0
7
0
20
0
7
0
7
7
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
0
% Q
% Arg:
27
0
27
0
0
7
14
0
7
0
0
0
7
7
0
% R
% Ser:
0
27
20
14
20
54
14
47
14
34
34
14
40
0
7
% S
% Thr:
20
0
0
7
7
7
14
0
0
0
0
0
0
0
0
% T
% Val:
7
7
0
14
7
7
0
0
0
0
0
0
0
14
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _